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Cocaine poses fascinating difficulties for neurophysiologists and neuropharmacologists and there's vital new facts at the results of cocaine at the mind (its preliminary website of motion on the mobile point now showing to be the dopamine transporter). comprises chapters at the far-reaching poisonous results of cocaine, at the epidemiology and the economics of drug dependancy, at the earlier and current use of cocaine within the U.S. and in South the US, and at the ethical matters raised by way of drug use and abuse.

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Extra info for Cocaine: Scientific and Social Dimensions (Novartis Foundation Symposia)

Sample text

Holding constant any or all of these three measures of depression did not change the relationship between cocaine use and occurrence of suicide attempt, except to make the association more potent. This evidence suggests that ‘confounding’ by pre-existing depression is not the explanation of the link we found between cocaine use and making a suicide attempt. Now, we admit that there are other ways to measure a history of depression, and there are other risk factors that we did not hold constant in this study.

A second measure involved a less specific syndrome of depression, which did not make much difference, once we took into account the lifetime history of major depression. The third measure was simply a selfreport to identify those persons who had had a period of two weeks in their lives when they had felt sad or blue, or had lost all interest in their usual activities. Holding constant any or all of these three measures of depression did not change the relationship between cocaine use and occurrence of suicide attempt, except to make the association more potent.

A total of 40 adults in the sample reported making suicide attempts during the observation interval; these were our suicide attempt ‘cases’. One to 17 noncases were grouped with each case by Census tract of household residence and 30 Anthony by age (4 + / -years). The grouping by Census tract of residence effectively matched for, and held constant, suspected macrosocial influences on suicidal behaviour, some of which have figured prominently in the sociological literature on suicide. As described in relation to the study of cocaine use, this strategy allowed us to sharpen our focus on personal and behavioural attributes suspected of influencing the risk of making a suicide attempt, including recent use of cocaine (Petronis et a1 1990).

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