Download CHRONOPHARMACEUTICS - Science and Technology for Biological by Bi-Botti C. Youan PDF

By Bi-Botti C. Youan


Science and expertise for organic Rhythm Guided remedy and Prevention of Diseases

Edited by means of

Bi-Botti C. Youan

The first general reference on chronopharmaceutics

As we larger know how organic methods spread in genuine time via advances in chronobiology and similar fields, we will be able to create more secure, more suitable medicines, drug supply structures, and affliction tracking and prevention structures. while administered in right coordination with a patient's physique rhythms, such medicinal drugs can maximize healing final result whereas minimizing negative effects. Chronopharmaceutics provides the 1st typical reference textual content in this rising cross-disciplinary box and its strength for healing and preventive medicine.

Bringing jointly the newest findings from skilled investigators, this edited paintings offers a much-needed unmarried resource on chronopharmaceutics. After an creation that features a timeline of key discoveries, an summary of regula-tory, formula, production and key source matters linked to chronopharmaceutics, the exact insurance examines:

  • Chronopharmacokinetics

  • Chronotherapy

  • Controlled free up structures prompted through actual and/or chemical activation

  • Chronopharmacodynamics, chronomics, and anesthesia

  • Markers-guided chronotheranostics

Filling a niche in either the graduate lecture room and the operating business or learn laboratory, Chronopharmaceutics bargains scholars, teachers, and execs a special and accomplished reference for this state of the art box.

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S. Department of Health and Human Services (DHHS) announced efforts between the FDA and the Centers for Medicare & Medicaid Services (CMS) to enhance patient safety as well as the quality of medical care patients receive. These collective efforts included the CMS regulations and the Sentinel Initiative. The CMS regulations now enable federal agencies, states, and academic researchers to use Medicare prescription drug claims data for public health research and analysis; The Sentinel Initiative: National Strategy for Monitoring Medical Product Safety describes a new program that includes the creation of an electronic system for assessing information to detect potential postmarket adverse events.

5 Biological Rhythms, Health, and Diseases . . . . . . . . . . . . 1 Biological Rhythms and Sleep Disorders. . . . . . . . . . 2 Biological Rhythms and Respiratory Diseases. . . . . . . . 3 Biological Rhythms and Cancer . . . . . . . . . . . . . 4 Biological Rhythms and Cardiovascular Diseases . . . . . . . 5 Biological Rhythms and Neurodegenerative Diseases . . . . . 6 Biological Rhythms and Metabolic Disorders.

2 Chronopharmacokinetic and Chronopharmacodynamic Resources. 3 Genetics and Molecular Biology Resources . . . . . . . . . 4 Ethical and Regulatory Resources . . . . . . . . . . . . Conclusion and Future Perspectives . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . 32 32 33 34 34 36 37 OBJECTIVES The objectives of this introductory chapter are to (1) introduce this emerging concept of chronopharmaceutics, (2) provide a chronology and comprehensive background literature that support the demand, (3) broadly review diseases for which knowledge gained would be beneficial, (4) classify the chronopharmaceutical drug delivery systems (ChrDDSs) that are on the market or under development, and (5) provide potential resources that may help in future investigation.

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