Download Chemistry of Heterocyclic Compounds: Azepines, Part 1, by Andre Rosowsky PDF

By Andre Rosowsky

Content material:
Chapter I Dibenzazepines and different Tricyclic Azepines (pages 1–635): Burt Renfroe and Clinton Harrington
Chapter II Azepine Ring structures Containing jewelry (pages 637–768): George R. Proctor

Show description

Read Online or Download Chemistry of Heterocyclic Compounds: Azepines, Part 1, Volume 43 PDF

Best general & reference books

Technische Katalyse

With no catalysts commercial creation, study and environmental expertise might all be unthinkable. even supposing eighty% of all large-scale commercial procedures are catalytic, many scientists and engineers restrict themselves to continuing on empirical traces. they often don't own the elemental wisdom for a scientific improvement and alertness of catalysts.

Industrial Biotechnology: Sustainable Growth and Economic Success

Describing all themes of white biotechnology admitted to the seventh european body Programme and new commercial creation tactics aiming in the direction of the Kyoto goals, this complete evaluation covers the know-how, purposes, fiscal power and implications for society. Directed at readers with a basic curiosity in a selected expertise, this can be both appropriate as an introductory guide to a variety of industries, together with chemical substances, biotechnology and prescription drugs, nutrients and feed, paper and pulp, own care, strength and agriculture.

Characterization of Flow, Particles and Interfaces

Multi-scale research and simulation of chemical processing and reactions have got exceptional cognizance lately; in spite of the fact that, size expertise excited by multi-scale constructions, fairly on meso-scale phenomena, has now not been sufficiently addressed.  This quantity of Advances in Chemical Engineering specializes in the "Characterization of circulation, debris and Interfaces" to alert the chemical engineering neighborhood to this not easy factor proposing six meso-scale dimension applied sciences.

The Story of Early Chemistry

This can be a iteration of the unique 1924 variation.

Extra resources for Chemistry of Heterocyclic Compounds: Azepines, Part 1, Volume 43

Sample text

27) to the hexahydro[l,2albenzimidazole 164 in 90% yield (41). Later, performic acid (98% formic acid plus 30% hydrogen peroxide) was reported to accomplish this same conversion in 80-90% yields (42,43). The hexahydro compound 164 was also obtained in good yield (44)via a straightforward annulative alkylation of the 2-bromoalkylbenzimidazole 165a (Fig. 22). A related, patented process (45) claims the acid-catalyzed cyclization of 165b, prepared from o-phenylene- 161 GQ H2N 163 0,a 162 [CF,CO,Hl CF,CO,H + 30% H 2 0 2 , N 164, 90%; rnp 124-125°C 40 Dibenzazepines and Other Tricyclic Azepines diamine and caprolactam, to 164 in 85% yield.

41 5,6,7-Systems R2 R2 167 166 166a 166b H NHAc 167a 167b NHAc H 222 252 66 58 R, R2 m p ("C) H N, N, H 98 108 167 HOAc. PPA. )low heat lo 14s"C Me 168, 68% 169, 66% Figure 23 (Eq. 28) gave a product having chemical and physical properties at variance with structure 171 (47). The product had an ultraviolet absorption spectrum similar to those of 2-alkylbenzimidazoles and proved to be identical with the product obtained via the decomposition of 161 (X = H). Yields of 164 from 170 were relatively poor: 21% with ferrous oxaiate as the reductant and only 15% using iron.

An oxaziridine similar to that in Fig. 29 was proposed as an intermediate leading to 188. I H 0 176 O2N I OTs Figure 29 186 Dibenzazepines and Other Tricyclic Azepines 48 TABLE 13. PRODUCTS FROM IRRADIATION OF BENZIMIDAZOLE N-OXIDES 1 8 7 R Product Yield (7%) H 187 188 189 187 188 190 42 25 32 12 44 CI “Eq. 30. I 188 0 (30) 187 + R ~Q+Meo c1 N 189 191 N 190 193 192 + 195, mp 144°C 194 Figure 30 IV. 49 5,6,7-Systems Anils derived from o-pyrrolidinoaniline and a wide variety of aldehydes were found to undergo a rapid acid-catalyzed cyclization in the cold to give dihydrobenzimidazoles (57).

Download PDF sample

Rated 4.97 of 5 – based on 12 votes